Gene T Yocum Selected Research

Asthma (Bronchial Asthma)

1/2022	Comparative pharmacodynamic and pharmacokinetic study of MIDD0301 and its (S) enantiomer.
12/2020	Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models.
11/2020	Reduced allergic lung inflammation and airway responsiveness in mice lacking the cytoskeletal protein gelsolin.
1/2020	Agonism of the TMEM16A calcium-activated chloride channel modulates airway smooth muscle tone.
1/2020	Ginger and its bioactive component 6-shogaol mitigate lung inflammation in a murine asthma model.
1/2019	A novel GABAA receptor ligand MIDD0301 with limited blood-brain barrier penetration relaxes airway smooth muscle ex vivo and in vivo.
1/2018	A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung.
1/2017	Optimization of substituted imidazobenzodiazepines as novel asthma treatments.
1/2016	Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments.

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Gene T Yocum Research Topics

Disease

9	Asthma (Bronchial Asthma) 01/2022 - 01/2016
6	Respiratory Hypersensitivity 01/2023 - 01/2016
5	Pneumonia (Pneumonitis) 02/2022 - 01/2020
5	Inflammation (Inflammations) 01/2022 - 01/2017
2	Bronchial Spasm 12/2020 - 01/2020
2	Cognitive Dysfunction 04/2010 - 05/2009
1	Respiratory Insufficiency (Respiratory Failure) 12/2020
1	Cystic Fibrosis (Mucoviscidosis) 01/2020
1	Cough 01/2017
1	Neoplasms (Cancer) 03/2006
1	Glioma (Gliomas) 03/2006

Drug/Important Bio-Agent (IBA)

4	Methacholine Chloride (Methacholine)FDA Link 01/2023 - 01/2017
4	MIDD0301IBA 01/2022 - 01/2018
4	OvalbuminIBA 12/2020 - 01/2016
3	LipopolysaccharidesIBA 02/2022 - 12/2020
3	LigandsIBA 01/2018 - 01/2017
2	Albuterol (Salbutamol)FDA LinkGeneric 02/2022 - 12/2020
2	SteroidsIBA 02/2022 - 12/2020
2	AntigensIBA 11/2020 - 01/2020
1	InterferonsIBA 01/2022
1	Interferon-gamma (Interferon, gamma)IBA 12/2020
1	Fluticasone (Cutivate)FDA LinkGeneric 12/2020
1	AllergensIBA 12/2020
1	Proteins (Proteins, Gene)FDA Link 11/2020
1	Chemotactic FactorsIBA 11/2020
1	GelsolinIBA 11/2020
1	CytokinesIBA 11/2020
1	(3,4,5- trimethoxy- N- (2- methoxyethyl)- N- (4- phenyl- 2- thiazolyl)benzamideIBA 01/2020
1	ginger extractIBA 01/2020
1	BenzbromaroneIBA 01/2020
1	shogaolIBA 01/2020
1	IsotopesIBA 01/2017
1	CationsIBA 01/2017
1	AerosolsIBA 01/2016
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 05/2009
1	erucylphosphocholineIBA 03/2006
1	Protamines (Protamine Sulfate)FDA Link 03/2006

Therapy/Procedure

2	Oral Administration 01/2022 - 01/2018
2	Therapeutics 01/2020 - 01/2016
2	Carotid Endarterectomy 04/2010 - 05/2009